College Football Picks: South Alabama-LSU Prediction, Odds | Sports betting

The South Alabama Jaguars and LSU Tigers meet on Saturday, September 28th in what should be a high-scoring game. In terms of betting odds, LSU is the favorite with 21.5 points, the overall odds are an impressive 65.5.

South Alabama's offense has been red-hot lately, scoring a combined 135 points against Appalachian State and Northwestern State. The Jaguars will now look to step up their game to see if their offense can hold up against an LSU defense that struggled at times early in the season.

Which team will be ahead on Saturday? We break down the matchup to find out.

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South Alabama Jaguars vs LSU Tigers odds

LSU -21.5

Overall: 65.5

Moneyline: LSU -1600, South Alabama +900

Odds courtesy of DraftKings Sportsbooks

Prediction for South Alabama Jaguars vs. LSU Tigers

Do you like points? If so, South Alabama-LSU is probably the game for you. As the high overall score of 65.5 suggests, this is a duel between two good offenses and a weak defense.

South Alabama enters Saturday's matchup ranked 13th in total offense and averaging over 48 points per game. Meanwhile, LSU is averaging 33.5 points per game, although its offense has taken a step back after losing three picks in the first round of the NFL Draft to last season's top-ranked unit.

These numbers are a bit misleading since LSU has a much tougher schedule ahead of them, but there's no denying the Jaguars' offense is picking up steam heading into Saturday's game. Unfortunately, the same cannot be said for South Alabama's defense. The Jaguars rank 107th in total defense, allowing 449 yards per game.

LSU's offense was efficient, but the Tigers are still looking for a standout performance. There were glimpses like in the second halves against South Carolina and UCLA, although we'll wait for Garrett Nussmeier and Co. to play well for a full four quarters. This breakthrough should happen on Saturday.

A big surprise for LSU through four games is its mediocre rushing attack. LSU was expected to have one of the best offensive lines entering the season, but the Tigers rank a disappointing 96th in rushing offense with just 117 yards per game.

I expected LSU to knock off a bad UCLA squad last week, but that didn't happen. I'll be honest, this performance raises red flags for me because of how bad the Bruins have been this season. Still, I expect the Tigers offense to get rolling against an overpowering South Alabama defense.

The overall score of 65.5 is a bit high for me, so I'm approaching this game differently. I like the LSU team overall over 43.5. South Alabama lost 52 to North Texas earlier this season and I think we'll see a similar result in this matchup. If LSU's offense can't dominate against one of the worst defenses in the country, it's time to hit the panic button.

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Choice between South Alabama Jaguars and LSU Tigers

LSU team total points over 43.5 (DraftKings)