Biggest challenge for any current NFL division head to maintain leadership; MVP rankings

Biggest challenge: Run the defense.

Admittedly there is some recency bias here, but how could that be? not Be? The Bills got off to a 3-0 start until the ball literally went down their throats on Sunday night. It wasn't that Buffalo didn't know what was coming. It's also not like the Bills were bad against the run before Week 4 (that wasn't the case). It's just that Buffalo hasn't faced a rushing attack like Baltimore's in its first three wins, and its weaknesses immediately became apparent when it finally gave up 271 yards on the ground. As soon as Derrick Henry hit an 87-yard touchdown run on Baltimore's first offensive play, you knew it was going to be a long night for Buffalo.

The Bills don't field the strongest defense and are missing their two best linebackers (Matt Milano and Terrel Bernard). These factors would eventually get to this team, and it simply resulted in a 35-10 loss in front of a nationally televised audience. Buffalo will certainly look better against the run in the coming weeks, especially since its next five games will be against teams that rank in the bottom half of the league in rushing. But this is something to remember. It was so bad against Baltimore.